SML1270

YZ9

≥98% (HPLC)

• Synonym(e): 3-Carbethoxy-7-hydroxycoumarin, 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester
• Empirische Formel (Hill-System): C₁₂H₁₀O₅
• CAS-Nummer: 6093-71-6
• Molekulargewicht: 234.20
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: [o]1c2c(cc([c]1=O)C(=O)OCC)ccc(c2)O
• InChI: 1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3
• InChI key: IETDBZQIWIJQJG-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

PFKFB3 inhibitor

YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.[1]

YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC₅₀ = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable