T3830

Triciribine hydrate

≥97% (HPLC)

• Synonym(e): API-2, Akt/PKB Signaling Inhibitor-2, Inhibitor V, NSC 154020, TCN, VD-0002
• Empirische Formel (Hill-System): C₁₃H₁₆N₆O₄ · xH₂O
• CAS-Nummer: 35943-35-2
• Molekulargewicht: 320.30 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329826778
• UNSPSC Code: 12352200
• MDL number: MFCD16879015
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: tan
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24
• InChI: 1S/C13H16N6O4.H2O/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13;/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17);1H2/t6-,8-,9-,13-;/m1./s1
• InChI key: SPGRLWCWHWRPHX-DOKXERMVSA-N
• Gene Information: human ... AKT1(207) ; mouse ... AKT1(11651) ; rat ... AKT1(24185)

Beschreibung

Application

Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells¹. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)².

Biochem/physiol Actions

Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Triciribine hydrate is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable