SRP5075

PTPN2, active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): PTPT, TCELLPTP, TCPTP
• NACRES: NA.32
• UNSPSC Code: 12352200
• Specific activity: 6928-9372 nmol/min·mg
• Assay: ≥70% (SDS-PAGE)
• Recombinant: expressed in E. coli

Eigenschaften

• recombinant: expressed in E. coli
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 6928-9372 nmol/min·mg
• mol wt: ~69 kDa
• NCBI accession no.: NM_080422
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... PTPN2(5771)

Beschreibung

General description

Research Area: Cell Signaling
Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.

Biochem/physiol Actions

Protein tyrosine phosphatase, non-receptor type 2 (PTPN2) regulates interferon signaling and the endoplasmic reticulum stress response in pancreatic β-cells during autoimmune diabetes. It serves as a crucial prognostic marker that influences the progression of pancreatic adenocarcinoma (PAAD) by activating the JAK-STAT signaling pathway. Silencing PTPN2 leads to a significant reduction in PAAD cell growth, migration, and invasion, while also triggering cell cycle arrest and apoptosis in PAAD cells.

Physical form

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• signalword: Danger
• hcodes: EUH451
• pcodes: P201 - P202 - P273 - P391 - P501
• Hazard Classifications: vPvM