SRP5074

PTPN13 (2169-2485), active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): DKFZp686J1497, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE
• NACRES: NA.77
• UNSPSC Code: 12352200
• Specific activity: 2040-2760 nmol/min·mg
• Assay: ≥70% (SDS-PAGE)
• Recombinant: expressed in E. coli

Eigenschaften

• recombinant: expressed in E. coli
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 2040-2760 nmol/min·mg
• mol wt: ~61 kDa
• NCBI accession no.: NM_080683
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... PTPN13(5783)

Beschreibung

General description

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis.

Physical form

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Signalwort: Danger
• Gefahrencodes: EUH451
• Sicherheitshinweise: P201 - P202 - P273 - P391 - P501
• Hazard Classifications: vPvM