SRP5073

PTPN12 (1-355), active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): PTPG1, tcag7.1075
• NACRES: NA.32
• UNSPSC Code: 12352200
• Specific activity: 2520-3410 nmol/min·mg
• Assay: ≥70% (SDS-PAGE)
• Recombinant: expressed in E. coli

Eigenschaften

• recombinant: expressed in E. coli
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 2520-3410 nmol/min·mg
• mol wt: ~66 kDa
• NCBI accession no.: NM_002835
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... PTPN12(5782)

Beschreibung

General description

Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events.

Physical form

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Signalwort: Danger
• Gefahrencodes: EUH451
• Sicherheitshinweise: P201 - P202 - P273 - P391 - P501
• Hazard Classifications: vPvM