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SRP0125
LSD1 substrate (Di-methylated K4_H3)
≥90% (HPLC), aqueous solution
Synonym(e):
HIST1H3E, Histone H3.1
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
500 μL | Versand in der Regel in 2 Wochen. | € 294,00 |
Über diesen Artikel
UNSPSC Code:
12352204
NACRES:
NA.32
€ 294,00
Versand in der Regel in 2 Wochen.
Technischer Dienst
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Unterstützung erhaltenProduktname
LSD1 substrate (Di-methylated K4_H3), ≥90% (HPLC)
biological source
human
assay
≥90% (HPLC)
form
aqueous solution
mol wt
2283 Da
packaging
pkg of 500UL
concentration
0.55 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HIST1H3E(8353)
General description
Lysine-specific demethylase 1 (LSD1) acts on mono- and dimethylated histones and demethylates them. It has a role in embryogenesis, cell proliferation, spermatogenesis, adipogenesis and chromosomal segregation. Histone H3 peptide methylated at Lysine 4 is a substrate for LSD1. Histone cluster 1 H3 family member E (HIST1H3E) is a variant of histone 3 and is also called as the replicative histone. It is mainly expressed in the S-phase of the cell cycle. The gene encoding this protein is localized on human chromosome 6p22.
Application
Study enzyme kinetics and screen small molecular inhibitors of LSD1 for drug discovery and HTS applications
Biochem/physiol Actions
Histones have an important role in the organization and modification of chromatin. Histone cluster 1 H3 family member E (HIST1H3E) has a role in DNA synthesis during DNA replication and might also be involved in DNA repair. It is deposited at the chromatin at the time of DNA replication-associated chromatin assembly. During herpes simplex virus 1 (HSV-1) infection, differential movement of HIST1H3E is associated with the assembly of viral chromatin.
Physical form
Supplied as 500 uL of water solution at 200 uM concetration.
Preparation Note
Thaw on ice. Upon first thaw, briefly spin tube to recover full content of the tube. Aliquot into single use aliquots. Store remaining product in aliquots at -70°C. Note: Avoid freeze/thaw cycles.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥90% (HPLC) | description ≥90% (HPLC) | description recombinant, expressed in E. coli, ≥80% (SDS-PAGE) | description from rabbit, purified by affinity chromatography |
| assay ≥90% (HPLC) | assay ≥90% (HPLC) | assay ≥80% (SDS-PAGE) | assay - |
| biological source human | biological source human | biological source human | biological source rabbit |
| form aqueous solution | form aqueous solution | form aqueous solution | form - |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| mol wt 2283 Da | mol wt ~2 kDa | mol wt 15.4 kDa | mol wt - |
Lagerklasse
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the Department of Transportation shipping information for this product?
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What is the sequence of the peptide for Product SRP0125, LSD1 substrate (Di-methylated K4_H3)?
1 answer-
Product SRP0125 is a 21 amino acid peptide. The sequence is:ARTK*QTARKSTGGKAPRKQLA, where K* is dimethylated lysine.The sequence of the peptide corresponds to the N-terminal (minus the methionine) portion of human Histone H3, with the K4 (lysine at position 4) dimethylated.
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