SML1314

SAG dihydrochloride

≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist

• Synonym(e): 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide dihydrochloride, Smoothened Agonist
• Empirische Formel (Hill-System): C₂₈H₂₈ClN₃OS · 2HCl
• CAS-Nummer: 912545-86-9
• Molekulargewicht: 562.98
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825779
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: lyophilized solid
• Storage condition: desiccated

Eigenschaften

• Produktname: SAG dihydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: lyophilized solid
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
• InChI: 1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
• InChI key: VFSUUTYAEQOIMW-YHBQERECSA-N

Beschreibung

Application

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:

• to study its effects on mouse hippocampal cells
• to determine its effects on the mitochondrial network in zebrafish embryo
• to study its effects on murine embryonic fibroblasts

Biochem/physiol Actions

SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.

SAG is a potent and cell-permeable smoothened (Smo) agonist.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H413
• pcodes: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable