SML0521

ML 210

≥98% (HPLC), GPX4 inhibitor, powder

• Synonym(e): CID 49766530, ML-210, [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• Empirische Formel (Hill-System): C₂₂H₂₀Cl₂N₄O₄
• CAS-Nummer: 1360705-96-9
• Molekulargewicht: 475.32
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825528
• NACRES: NA.77
• MDL number: MFCD22666407
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: ML 210, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• storage temp.: 2-8°C
• SMILES string: Cc1onc(C(=O)N2CCN(CC2)C(c3ccc(Cl)cc3)c4ccc(Cl)cc4)c1[N+]([O-])=O
• InChI: 1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
• InChI key: VIBHJPDPEVVDTB-UHFFFAOYSA-N

Beschreibung

Application

ML 210 has been used as a glutathione peroxidase 4 (GPX4) inhibitor to induce ferroptosis in cancer cells. It has also been used as a GPX4 inhibitor to examine whether pharmacological inhibition of GPX4 altered prominin2 expression and impacted ferroptosis in adherent MCF10A and Hs578t cells.

Biochem/physiol Actions

ML 210 induces cell death in RAS expressing tumor cells.

ML 210 induces non-apoptotic cell death in tumor cells expressing the RAS oncogene.

ML 210 acts as a selenoenzyme glutathione peroxidase 4 (GPX4) inhibitor. It exhibits cytotoxicity against few ovarian cancer cell lines.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable