The product was lyophilized from a mixture of water and acetonitrile containing 0.1 % trifluoroacetic acid (the solvent used to purify the product by reverse-phase chromatography).
Fortfahren mit
SCP0094
Caspase Inhibitor
Synonym(e):
Ac-AEVD-CHO, caspase 6 inhibitor, caspase 8 inhibitor
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Versand in der Regel in 2 Wochen. | € 283,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C19H30N4O9
Molekulargewicht:
458.46
NACRES:
NA.32
UNSPSC Code:
12352200
€ 283,00
Versand in der Regel in 2 Wochen.
Technischer Dienst
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Unterstützung erhaltenassay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Gene Information
human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842)
General description
Currently, there are 13 caspases recognized in mammals. Caspases are classified as initiators and effectors. Caspase 8 belongs to the class of initiators. It possesses a prodomain at the terminal and contains the death effector domain which serves as protein-protein interaction motif for caspase 8. With respect to substrate specificity, caspase 8 is classified as a member of group III. It specifically recognizes the (I/L/V) EXD sequence on the substrate.
Application
Caspase Inhibitor has been used to study the specificity of the CIL-1 (desglucoanagalloside B) interaction with the caspase 3/7 system.
Biochem/physiol Actions
The peptide Ac-Ala-Glu-Val-Asp-al, or Ac-AEVD-CHO, is an inhibitor of Group III caspases. It acts upon caspases-6, 8, 9, and 10, with particular effectiveness on caspase-6 and caspase-8. The use of Ac-AEVD-CHO in several apotosis studies has been reported.
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Dieser Artikel | |||
|---|---|---|---|
| description - | description ≥95% (HPLC) | description Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor. | description The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay - | assay ≥90% (HPLC) |
| Gene Information human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842) | Gene Information human ... CASP8(841), CASP9(842) | Gene Information - | Gene Information - |
| form lyophilized | form lyophilized | form solid | form solid |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| storage condition protect from light | storage condition protect from light | storage condition desiccated, OK to freeze | storage condition OK to freeze |
| composition Peptide Content, ≥80% | composition Peptide Content, ≥80% | composition - | composition - |
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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In what type of buffer is the lyophilisate resuspended?
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