Renin (angiotensinogenase) which hydrolyzes angiotensinogen is a component of the renin-angiotensin system (RAS) that regulates vasoconstriction and blood pressure. Angiotensinogen 1-14 (DRVYIHPFHLLVYS) may be used as a substrate for renin. A variety of renin substrates may be built around the minimal sequence His-Pro-Phe-His-Leu-Leu-Val-Tyr (HPFHLLVY).
Rosettes are widely used in epithelial morphogenesis during embryonic development and organogenesis. However, their role in postnatal development and adult tissue maintenance remains largely unknown. Here, we show zona glomerulosa cells in the adult adrenal cortex organize into rosettes through
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