SBR00057

Retapamulin

≥98% (HPLC)

• Empirische Formel (Hill-System): C₃₀H₄₇NO₄S
• CAS-Nummer: 224452-66-8
• Molekulargewicht: 517.76
• MDL-Nummer: MFCD11045316
• UNSPSC-Code: 51284706
• NACRES: NA.76

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Wirkungsspektrum von Antibiotika: Gram-positive bacteria
• Wirkungsweise: protein synthesis | interferes
• Lagertemp.: −20°C
• SMILES String: S(C4C[C@@H]5N([C@@H](CC5)C4)C)CC(=O)O[C@H]1[C@]2([C@H]3[C@@]([C@H]([C@@H]([C@](C1)(C)C=C)O)C)(CC[C@H]2C)CCC3=O)C
• InChI: 1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
• InChIKey: STZYTFJPGGDRJD-FJJJPKKESA-N

Beschreibung

Allgemeine Beschreibung

Retapamulin (RET) is a semi-synthetic antibiotic ointment, and pleuromutilin derivative compound.[1] The primary structural difference between pleuromutilin and retapamulin is in the C-14 side chain.[1]

Biochem./physiol. Wirkung

Retapamulin is a potent antibacterial agent against Gram-positive bacteria, especially against Staphylococcus aureus and S. pyogenes.[1] It displays synergistic effects against Enterococcus faecalis in combination with streptogramin (MLS).[2] RET initiates ribosomal arrests at the start codon and enables genes to use alternative translational sites in E. coli.[3]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable