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C5269

Clindamycin -hydrochlorid

lincosamide antibiotic

Synonym(e):

(7S)-7-Chloro-7-deoxylincomycin -hydrochlorid, Cleocin

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Ihnen/SKUVerfügbarkeitPreis
10 mg
Warenkorb auf Verfügbarkeit prüfen
€ 155,00
50 mg
Warenkorb auf Verfügbarkeit prüfen
€ 515,00
100 mg
Warenkorb auf Verfügbarkeit prüfen
€ 887,00

Über diesen Artikel

Empirische Formel (Hill-System):
C18H33ClN2O5S · HCl
CAS-Nummer:
Molekulargewicht:
461.44
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4070786

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Quality Segment

form

powder or crystals

impurities

≤13%

solubility

H2O: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1

InChI key

AUODDLQVRAJAJM-XJQDNNTCSA-N

General description

Chemische Struktur: Makrolid

Application

Clindamycin wird verwendet, um bakterielle Infektionen, wie die Infektion mit Streptokokken der Gruppe B, bakterielle Resistenz und die Plasmaproteinbindung zu untersuchen.[1][2][3]
Wird zur Untersuchung der bakteriellen Proteinsynthese verwendet.

Biochem/physiol Actions

Clindamycin ist ein halbsynthetisches Lincosamid-Antibiotikum, das aus Lincomycin hergestellt wird. Es hemmt die bakterielle Proteinsynthese durch Wasserstoffbindungsinteraktionen mit der rRNA-Komponente 23S der ribosomalen Untereinheit 50S und induziert damit die Auflösung des Peptidyl-t-RNA-Komplexes. Es wirkt antibakteriell gegen grampositive Kokken und antiprotozoisch gegen Taxoplasma.
Clindamycinhydrochlorid ist hochwirksam gegen anaerobe Spezies.[4]

Other Notes

Antibakterielles und antiprotozoisches Antibiotikum der Lincosamid-Klasse.
Behälter dicht verschlossen an einem trockenen und gut gelüfteten Ort aufbewahren.

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Dieser Artikel
1136002C2250000PHR1159
mode of action

protein synthesis | interferes

mode of action

-

mode of action

-

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

300

form

powder or crystals

form

-

form

-

form

-

solubility

H2O: 50 mg/mL

solubility

-

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-10 to -25°C


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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Lact. - Skin Sens. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

1–7 of 7 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the potency of this product?

    1 answer
    1. The potency of Product C5269 (Clindamycin hydrochloride) exceeds 800ug of Clindamycin/mg.

      Helpful?

  4. You list the purity of Clindamycin hydrochloride, Product C5269, as determined by thin layer chromatography. Is it possible to determine purity by other chromatographic methods?

    1 answer
    1. The USP 31 describes a liquid chromatographic method utilizing Clindamycin Hydrochloride and Lincomycin Hydrochloride standards. Other publications may be searched on PubMed, such as G. La Follette et al.,  J Chromatogr., Vol. 431 (No. 2), pp. 379-388 (1988).

      Helpful?

  5. What is the pH of an aqueous solution of Clindamycin hydrochloride, Product C5269?

    1 answer
    1. The expected pH of a 100 mg/ml aqueous solution is from 3.0 to 5.5, per USP 31, p. 1796.

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  6. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  7. What is the antibiotic potency of Clindamycin hydrochloride, Product C5269?

    1 answer
    1. We do not include the potency of the compound in our quality specifications. Please contact Sigma-Aldrich Technical Service for the availability of lot-specific potency from our supplier.

      Helpful?

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