Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Twist (NP_000465.1).
Physikalische Form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
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