SAB2701683
Anti-th antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(e):
th, tyrosine hydroxylase
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About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Speziesreaktivität
zebrafish
Methode(n)
western blot: 1:500-1:3000
NCBI-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
zebrafish ... th(30384)
Allgemeine Beschreibung
Tyrosine hydroxylase (TH) is a cytoplasmic enzyme. The TH gene codes for a monooxygenase.
Immunogen
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 111 and 450 of th according to NP_571224
Anwendung
Anti-th antibody produced in rabbit has been used in:
- western blotting (1:1000)
- whole retinal flat-mount immunolabelling (1:500)
- immunofluorescence (2:1000)
- immunohistochemistry (2:1000)
Biochem./physiol. Wirkung
Cell surface-associated protein is implicated in virulence. Promotes bacterial attachment exclusively to the γ-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus.
Tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, is essential for catecholamine biosynthesis. Its major role is to catalyze the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA). TH mainly serves as marker furcate cholaminergic neurons. Missense mutations in the TH gene are associated with Segawa′s syndrome, L-DOPA responsive infantile Parkinsonism, or L-DOPA responsive dystonia (DRD).
Leistungsmerkmale und Vorteile
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physikalische Form
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Aquatic Chronic 3 - Skin Sens. 1
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Chen Zhu et al.
Fitoterapia, 117, 47-51 (2017-01-09)
In this study, to study the effect of rhynchophylline on TH in midbrain of methamphetamine-induced conditioned place preference (CPP) adult zebrafish, place preference adult zebrafish models were established by methamphetamine (40μg/g) and the expression of TH was observed by immunohistochemistry
Dong-Jun Lv et al.
Behavioural brain research, 372, 112031-112031 (2019-06-14)
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the world. Apart from motor deficits, PD reduces patient's quality of life through sleep disturbances, cognitive impairment and emotional disorders. However, it's unclear whether bad life habits such as
Guney Bademci et al.
CNS & neurological disorders drug targets, 11(4), 469-481 (2012-05-16)
The tyrosine hydroxylase (TH) gene encodes a monoxygenase that catalyzes the rate limiting step in dopamine biosynthesis. A hallmark of Parkinson's disease (PD) is the loss of dopaminergic neurons in the substantia nigra. Consistent with the essential role of TH
Constance Pierre et al.
The Journal of experimental biology, 223(Pt 18) (2020-08-02)
The neurotransmitter serotonin controls a variety of physiological and behavioral processes. In humans, mutations affecting monoamine oxidase (MAO), the serotonin-degrading enzyme, are highly deleterious. Yet, blind cavefish of the species Astyanax mexicanus carry a partial loss-of-function mutation in MAO (P106L)
Soundhar Ramasamy et al.
The Journal of experimental biology, 222(Pt 1) (2018-11-18)
High fecundity, transparent embryos for monitoring the rapid development of organs and the availability of a well-annotated genome has made zebrafish a model organism of choice for developmental biology and neurobiology. This vertebrate model, which is also a favourite in
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