The solubility of this product is tested with DMSO at a concentration of 10 mg/mL. External sources also recommend using DMSO. A literature search indicates that this product has been utilized in in vitro assays targeting human neutrophil elastase as a positive control.
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S7198
Sivelestat sodium salt hydrate
≥98% (HPLC), HNE inhibitor, solid
Synonym(e):
EI 546 sodium salt hydrate, Elaspol sodium salt hydrate, LY 544349 sodium salt hydrate, Ono-5046 sodium salt hydrate, o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 104,00 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 429,00 € 364,65 |
Über diesen Artikel
Empirische Formel (Hill-System):
C20H22N2O7S · xNa+ · yH2O
CAS-Nummer:
Molekulargewicht:
434.46 (anhydrous free acid basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Technischer Dienst
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Unterstützung erhaltenProduktname
Sivelestat sodium salt hydrate, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
SMILES string
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
InChI
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key
BTGNGJJLZOIYID-UHFFFAOYSA-N
Application
Sivelestat sodium salt hydrate may be used to inhibit human neutrophil elastase-mediated cell signaling.
Biochem/physiol Actions
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC), solid | description ≥98% (HPLC) | description ≥95.0% (TLC) | description - |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay 95-102% anhydrous basis (corrected for sodium, T), ≥95.0% (TLC) | assay ≥98% (spectrophotometric assay), ≥98% (HPLC) |
| form solid | form powder | form powder or solid | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 300 |
| storage temp. room temp | storage temp. room temp | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: 5 mg/mL, clear | solubility - | solubility H2O: soluble 50 mg/mL, clear, colorless to faintly yellow |
| color white to off-white | color light yellow to dark yellow | color - | color - |
Lagerklasse
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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This compound can be used in in vitro assays targeting human neutrophil elastase as a positive control and is water-soluble?
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