PZ0213

PF-04418948

≥98% (HPLC)

• Synonym(e): 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
• Empirische Formel (Hill-System): C₂₃H₂₀FNO₅
• CAS-Nummer: 1078166-57-0
• Molekulargewicht: 409.41
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: Fc1ccc(cc1)C(=O)N2CC(C2)(COc3cc4c(cc(cc4)OC)cc3)C(=O)O
• InChI: 1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
• InChIKey: LWJGMYMNSNVCEM-UHFFFAOYSA-N

Beschreibung

Anwendung

PF-04418948 has been used in TG (trigeminal ganglion) explant culture.

Biochem./physiol. Wirkung

PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC₅₀ = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.

PF-04418948 is a PGE2 Receptor (EP2) specific antagonist.

PF-04418948 represses the formation of colorectal tumor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable