P4005

Protamine

solid

• Synonym(e): Protamine
• CAS-Nummer: 9012-00-4
• EG-Nummer: 232-726-0
• MDL-Nummer: MFCD00132089
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Protamine from salmon, Grade IV, Histone, free(Millon test)
• Biologische Quelle: fish (salmon)
• Typ: Grade IV
• Form: solid
• Verunreinigungen: Histone, free (Millon test)
• Löslichkeit: H₂O: soluble, clear to slightly hazy, colorless to faintly yellow
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Protamines are proteins rich in cysteine and arginine.[1] It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine.[2] It is found to be localized to the sperm head.[3]

Anwendung

Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin.[4] It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.[5]

Biochem./physiol. Wirkung

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.[6]

Protamines are found to displace histones in DNA during spermatogenesis[1] in animals and plants.[2] Protamine is useful as a heparin neutralizer during heart surgery, dialysis and in many other clinical procedures.[3]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)