P3338

Prostataspezifisches Antigen aus Humansperma

buffered aqueous solution

• Synonym(e): Krebs-assoziiertes PSA, PSA
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00165544
• Form: buffered aqueous solution
• Assay: ≥95% (SDS-GE)
• Biological source: human semen

Eigenschaften

• biological source: human semen
• Quality Segment: 200
• assay: ≥95% (SDS-GE)
• form: buffered aqueous solution
• UniProt accession no.: P07288
• storage temp.: 2-8°C
• Gene Information: human ... KLK3(354)

Beschreibung

General description

Prostate specific antigen (PSA) is a 28.43 kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is one of the highly abundant proteolytic enzyme expressed in the seminal fluid.

Application

Prostate Specific Antigen from human semen has been used:

• in microarray sandwich assay
• in the preparation of sandwich immunosensor
• as a target protein to test composite organic−inorganic nanoparticle (COIN) and Alexa conjugates in a plate-binding assay

Biochem/physiol Actions

Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa. Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M), and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.

Das prostataspezifische Antigen (PSA), ein Glykoprotein der glandulären Kallikrein-Familie, ist eine Serinprotease mit Chymotrypsin-ähnlicher enzymatischer Aktivität. Zirkulierendes PSA liegt in freien und an Proteasehemmern gebundenen Formen vor. Untersuchungen des Verhältnisses von freien und Hemmstoff-gebundenen Formen können sich bei der Diagnose von Prostatakrebs als hilfreich erweisen.

Glykoprotein der glandulären Kallikrein-Familie

Packaging

Package size based on protein content

Physical form

Solution in phosphate buffered saline, contains 0.05-0.1% sodium azide with 50% glycerol

Analysis Note

Highly purified

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable