O9387

Oxatomide

≥99%

• Synonym(e): 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
• Empirische Formel (Hill-System): C₂₇H₃₀N₄O
• CAS-Nummer: 60607-34-3
• Molekulargewicht: 426.55
• NACRES: NA.77
• PubChem Substance ID: 24278615
• UNSPSC Code: 51111800
• EC Number: 262-320-9
• MDL number: MFCD00211147
• Assay: ≥99%
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥99%
• form: powder
• color: white
• solubility: DMSO: soluble, ethanol: soluble
• originator: Johnson & Johnson
• SMILES string: O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5
• InChI: 1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
• InChI key: BAINIUMDFURPJM-UHFFFAOYSA-N
• Gene Information: human ... DRD3(1814)

Beschreibung

General description

Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.

Biochem/physiol Actions

Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.

Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Was ist los?: WGK 3
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves