N216

Monoclonal Anti-Na⁺/Ca²⁺ Exchanger antibody produced in mouse

clone C2C12

• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD01865491
• Conjugate: unconjugated
• Clone: C2C12, monoclonal
• Application: IHC (f), IP, WB
• Citations: 19

Eigenschaften

• biological source: mouse
• Quality Segment: 200
• conjugate: unconjugated
• antibody product type: primary antibodies
• clone: C2C12, monoclonal
• form: liquid
• mol wt: antigen 120 kDa (mature exchanger), antigen 160 kDa (non-reduced), antigen 70 kDa (proteolytic fragment)
• species reactivity: human, rat, canine, rabbit, guinea pig
• technique(s): immunohistochemistry (frozen sections): 1:200, immunoprecipitation (IP): suitable, western blot: 1:1,000
• isotype: IgM
• UniProt accession no.: P32418
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLC8A1(6546)

Beschreibung

General description

Na⁺/Ca²⁺ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters.

Immunogen

dog cardiac Na⁺/Ca²⁺ exchanger. The epitope is in the region of amino acids 371-525, which is on the intracellular side of the plasma membrane.

Biochem/physiol Actions

Na⁺/Ca²⁺ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca²⁺ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na⁺ or Ca²⁺.

The antibody reacts specifically with Na⁺/Ca²⁺ exchanger in kidney and cardiac tissues. By immunohistology, staining of the plasma membrane and intense staining of the cardiac T-tubular membrane is observed. The antibody is not recommended for immunoblotting of rat tissues.

Physical form

Solution in phosphate buffered saline, 1 mg/ml BSA containing 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)