N1537

NU7026

≥98% (HPLC), solid

• Synonym(e): 2-(Morpholin-4-yl)-benzo[h]chromen-4-one
• Empirische Formel (Hill-System): C₁₇H₁₅NO₃
• CAS-Nummer: 154447-35-5
• Molekulargewicht: 281.31
• NACRES: NA.77
• PubChem Substance ID: 329818582
• UNSPSC Code: 12352200
• MDL number: MFCD06798345
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: tan
• solubility: DMSO: soluble 3 mg/mL at 60 °C, H₂O: insoluble
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
• InChI: 1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
• InChI key: KKTZALUTXUZPSN-UHFFFAOYSA-N

Beschreibung

Application

Potent, ATP-competitive. IC₅₀ = 0.23 μM. Selectivity over other PI3K-related kinases (IC₅₀ = 13 μM for PI3K and >100 μM for ATM and ATR).

NU7026 has been used:

• as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
• in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
• to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)