N7537

NSC 663284

≥98% (HPLC), solid

• Synonym(e): 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• Empirische Formel (Hill-System): C₁₅H₁₆ClN₃O₃
• CAS-Nummer: 383907-43-5
• Molekulargewicht: 321.76
• NACRES: NA.77
• PubChem Substance ID: 24724556
• UNSPSC Code: 12352200
• MDL number: MFCD08276924
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: red
• solubility: DMSO: ≥10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• InChI key: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Gene Information: human ... CDC25B(994), DUSP3(1845), PTPN1(5770)

Beschreibung

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Biochem/physiol Actions

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: 470.1 °F
• flash_point_c: 243.4 °C
• ppe: dust mask type N95 (US), Eyeshields, Gloves