L1170

LY-487379 hydrochloride

≥98% (HPLC)

• Synonym(e): N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine hydrochloride
• Empirische Formel (Hill-System): C₂₁H₁₉F₃N₂O₄SHCl
• CAS-Nummer: 353229-59-1
• Molekulargewicht: 488.91
• MDL-Nummer: MFCD11519970
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 329817387

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: off-white
• Löslichkeit: DMSO: >20 mg/mL
• Ersteller: Eli Lilly
• Lagertemp.: 2-8°C
• SMILES String: Cl.COc1ccccc1Oc2ccc(cc2)N(Cc3cccnc3)S(=O)(=O)CC(F)(F)F
• InChI: 1S/C21H19F3N2O4S.ClH/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24;/h2-13H,14-15H2,1H3;1H
• InChIKey: LPWFRDWTOKLHJC-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC₅₀ = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable