K2638
Kallikrein from human plasma
buffered aqueous solution, ≥5 units/mg protein
Synonym(e):
Kininogenase, Kininogenin
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About This Item
CAS-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352204
NACRES:
NA.54
Empfohlene Produkte
Form
buffered aqueous solution
Qualitätsniveau
Spezifische Aktivität
≥5 units/mg protein
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Angaben zum Gen
human ... KLK1(3816)
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Allgemeine Beschreibung
Kallikrein-related peptidases belong to the family of 15 highly conserved trypsin- or chymotrypsin-like serine proteases. Plasma kallikrein (PK) is a serine protease derived from plasma prekallikrein, a zymogen found at higher levels in blood circulation. The KLKB1 gene is located on the human chromosome at 4q35.2.
Anwendung
Kallikrein from human plasma has been used:
- to culture human hepatocellular carcinoma cell line
- to study its effects on the cleavage of Neisserial heparin binding antigen (NHBA) from Neisseria meningitidis
- in peptidase inhibition assay
Biochem./physiol. Wirkung
Plasma kallikrein (PK) is involved in the synthesis of bradykinin, maintaining the blood metabolite levels and hypertension. It also participates in the activation of coagulation factor XII, which promotes inflammation and the intrinsic coagulation pathway. PK controls proteolytic cascades in the cardiovascular system like the kallikrein-kinin system, renin-angiotensin system, fibrinolytic system, and the alternative complement pathway. It is involved in the cleavage of glucagon-like peptide-1 (GLP-1) and neuropeptide Y (NPY) which suggests that plasma kallikrein may affect metabolism and diabetes.
Einheitendefinition
One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.
Physikalische Form
Solution in 20 mM Tris-HCl, pH 7.8 with 100 mM NaCl.
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Xueqing Xu et al.
Nucleic acids research, 37(22), 7381-7393 (2009-10-13)
A subtelomeric region, 4q35.2, is implicated in facioscapulohumeral muscular dystrophy (FSHD), a dominant disease thought to involve local pathogenic changes in chromatin. FSHD patients have too few copies of a tandem 3.3-kb repeat (D4Z4) at 4q35.2. No phenotype is associated
Elisa Pantano et al.
PloS one, 14(8), e0203234-e0203234 (2019-08-02)
Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein of Neisseria meningitidis and a component of the Bexsero vaccine. NHBA is characterized by the presence of a highly conserved Arg-rich region involved in binding to heparin and heparan sulphate proteoglycans
Georgia Sotiropoulou et al.
The Journal of biological chemistry, 284(48), 32989-32994 (2009-10-13)
Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1-15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that
R Dellalibera-Joviliano et al.
Scandinavian journal of immunology, 72(2), 128-133 (2010-07-14)
Some components of the kinin system such as plasma kallikrein levels, the activities of tissue kallikrein (including saliva) and kininase II and the concentrations of kininogen fractions (low-molecular weight/LKg and high-molecular weight/HKg) were evaluated in the plasma of patients with
Allen Clermont et al.
Diabetes, 60(5), 1590-1598 (2011-03-30)
Plasma kallikrein (PK) has been identified in vitreous fluid obtained from individuals with diabetic retinopathy and has been implicated in contributing to retinal vascular dysfunction. In this report, we examined the effects of PK on retinal vascular functions and thickness
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