K3627

Kallikrein from porcine pancreas

≥40 units/mg protein

• Synonym(e): Kininogenase, Kininogenin
• CAS-Nummer: 9001-01-8
• EG-Nummer: 3.4.21.35 (BRENDA, IUBMB)
• UNSPSC Code: 12352204
• EC Number: 232-574-5
• NACRES: NA.54
• MDL number: MFCD00131428
• Specific activity: ≥40 units/mg protein

Eigenschaften

• form: solid
• Quality Segment: 200
• specific activity: ≥40 units/mg protein
• storage temp.: 2-8°C

Beschreibung

General description

Kallikrein exists as an inactive prokallikrein in the porcine pancreas.[1] The porcine kallikrein gene region is localized on chromosome 6q12-q21.[2]

Application

Kallikrein from porcine pancreas has been used:

• as a matrix metalloproteinase-9 (MMP-9) zymogen activator[3]
• as a component of cell culture to test its effect on rat subventricular zone (SVZ) cells and oligodendrocyte progenitor cells (OPC) proliferation and survival[4]
• as a model enzyme to track kinetic data and visual detection limits of hydrolysis by hydrolytic enzymes in the two-phases array[5]

Biochem/physiol Actions

Kallikrein active forms are generated by the enzymatic action of trypsin.[1] It is a serine protease that mediates the activation of growth factors and substrates.[2]

Other Notes

One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H334,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)