I9910

Ibutilid -hemifumarat (Salz)

≥98% (HPLC), Class III antiarrhythmic agent, solid

• Synonym(e): (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt, Corvert
• Empirische Formel (Hill-System): C₂₀H₃₆N₂O₃S · 0.5C₄H₄O₄
• CAS-Nummer: 122647-32-9
• Molekulargewicht: 442.61
• UNSPSC Code: 12352200
• PubChem Substance ID: 329815470
• NACRES: NA.77
• MDL number: MFCD01715410
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Eigenschaften

• Produktname: Ibutilid -hemifumarat (Salz), ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white to tan
• solubility: H₂O: >20 mg/mL
• storage temp.: room temp
• SMILES string: OC(=O)\C=C\C(O)=O.CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1.CCCCCCCN(CC)CCCC(O)c2ccc(NS(C)(=O)=O)cc2
• InChI: 1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
• InChI key: PCIOHQNIRPWFMV-WXXKFALUSA-N
• Gene Information: human ... KCNH2(3757)

Beschreibung

Biochem/physiol Actions

Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent.

Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent. Ibutilide binds to and alters the activity of hERG potassium channels, delayed inward rectifier potassium (IKr) channels and L-type (dihydropyridine sensitive) calcium channels.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H361d
• pcodes: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable