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Merck

C4740

Cisaprid Monohydrat

≥98% (HPLC), 5-HT4 serotonin receptor agonist., solid

Synonym(e):

cis-4-Amino-5-chlor-N-[1-[3-(4-fluorphenoxy)-propyl]-3-methoxy-4-piperidinyl]-2-methoxybenxamid Monohydrat

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€ 127,00

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€ 485,35

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Über diesen Artikel

Empirische Formel (Hill-System):
C23H29N3O4ClF · H2O
CAS-Nummer:
260779-88-2
Molekulargewicht:
483.96
NACRES:
NA.77
PubChem Substance ID:
329775068
UNSPSC Code:
12352200
EC Number:
279-689-7
MDL number:
MFCD03305346
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

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Produktname

Cisaprid Monohydrat, ≥98% (HPLC), solid

InChI

1S/C23H29ClFN3O4.H2O/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16;/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29);1H2/t20-,22+;/m0./s1

InChI key

QBYYXIDJOFZORM-IKGOIYPNSA-N

SMILES string

O.CO[C@@H]1CN(CCCOc2ccc(F)cc2)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~30 mg/mL

originator

Johnson & Johnson

Quality Level

100

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1 of 4

Dieser Artikel
M2946SML1371SML0865
Cisapride monohydrate ≥98% (HPLC), solid

Sigma-Aldrich

C4740

Cisapride monohydrate

Mosapride citrate salt dihydrate

Sigma-Aldrich

M2946

Mosapride citrate salt dihydrate

Prucalopride ≥98% (HPLC)

Sigma-Aldrich

SML1371

Prucalopride

AA92593 ≥98% (HPLC)

Sigma-Aldrich

SML0865

AA92593

form

solid

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

DMSO: ~30 mg/mL

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

originator

Johnson & Johnson

originator

Takeda

originator

-

originator

-

color

white

color

-

color

white to beige

color

white to beige

Biochem/physiol Actions

5-HT4 serotonin receptor agonist.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000455984
0000455984
0000440380
0000440380
0000198214

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Die Dokumentenbibliothek aufrufen

Atsuko Inui et al.
Japanese journal of pharmacology, 90(4), 313-320 (2002-12-26)
It is known that 5-HT(4) receptors in the colon of guinea pigs show a distribution similar to that in humans. Thus, we examined the effects of mosapride citrate (mosapride) and cisapride, two 5-HT(4)-receptor agonists, on colonic motility in conscious guinea
Mihai Covasa et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 285(3), R641-R648 (2003-05-31)
MK-801, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, enhances gastric emptying while increasing food intake. Although our previously reported results implicate the vagus in MK-801's effect on feeding, it is not clear whether vagal motor fibers participate in the feeding response.
M R Briejer et al.
The Journal of pharmacology and experimental therapeutics, 274(2), 641-648 (1995-08-01)
In the guinea pig proximal colon, 5-hydroxytryptamine (5-HT) stimulates neuronal 5-HT1-like receptors to induce relaxations that are mediated by nitric oxide and ATP. In the current study, the effects of cisapride and structural analogs on these 5-HT-induced relaxations were investigated.
Haruka Nishimuta et al.
The AAPS journal, 21(2), 20-20 (2019-01-24)
Accurate prediction of human pharmacokinetics for drugs remains challenging, especially for non-cytochrome P450 (P450) substrates. Hepatocytes might be suitable for predicting hepatic intrinsic clearance (CLint) of new chemical entities, because they can be applied to various compounds regardless of the
Henry C Liu et al.
The Journal of pharmacology and experimental therapeutics, 359(1), 215-229 (2016-08-05)
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of machine-learning methods
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