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Keratinozyten-Wachstumsfaktor human
HumanKine®, >95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
Synonym(e):
FGF-7, KGF
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€ 398,00
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€ 398,00
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Produktbezeichnung
Keratinozyten-Wachstumsfaktor human, KGF, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Biologische Quelle
human
Rekombinant
expressed in HEK 293 cells
Assay
>95% (SDS-PAGE)
Form
lyophilized powder
Wirksamkeit
4-20 ng/mL EC50
Qualität
endotoxin tested
Mol-Gew.
dimer 17-30 kDa (glycosylated)
Verpackung
pkg of 10 μg
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
<1 EU/μg
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... FGF7(2252)
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Allgemeine Beschreibung
Anwendung
Keratinocyte Growth Factor (KGF) human has been used as a component of the keratinocyte differentiation medium.[4]
Biochem./physiol. Wirkung
Keratinocyte Growth Factor (KGF) exerts paracrine effects on mesenchymal cells. It exhibits cryoprotective effects on epithelial cells of the lungs, gastrointestinal tract, and the lungs.[1] KGF participates in the activation of IIIb isoform of the fibroblast growth factor (FGF)-receptor 2 (FGFR2-IIIb) present on keratinocytes. This activation further favors proliferation, migration, and survival of keratinocytes.[2]
Physikalische Form
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Angaben zur Herstellung
HumanKine Keratinocyte Growth Factor (KGF) is expressed as glycosylated 17 and 30 kDa monomers in human HEK 293 cells. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Hinweis zur Analyse
The activity was determined by the dose-dependent stimulation of the proliferation of 4MBr-5 cells (monkey epithelial cell line).
Rechtliche Hinweise
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Michael J LaFemina et al.
American journal of physiology. Lung cellular and molecular physiology, 299(6), L724-L734 (2010-09-14)
Keratinocyte growth factor (KGF) has efficacy in several experimental models of lung injury; however, the mechanisms underlying KGF's protective effect remain incompletely understood. This study was undertaken to determine whether KGF augments barrier function in primary rat alveolar epithelial cells
Qandeel Fatima et al.
Open life sciences, 13, 544-552 (2018-12-31)
Autologous skin grafts are used to treat severe burn wounds, however, the availability of adequate donor sites makes this option less practical. Recently, stem cells have been used successfully in tissue engineering and in regenerative medicine. The current study aims
Susanne Braun et al.
Journal of cell science, 119(Pt 23), 4841-4849 (2006-11-09)
Owing to its potent cytoprotective properties for epithelial cells, keratinocyte growth factor (KGF) is successfully used for the treatment of chemotherapy- and radiotherapy-induced oral mucositis in cancer patients. It is therefore of major interest to determine possible clinical applications of
Umbilical cord tissue derived mesenchymal stem cells can differentiate into skin cells
Fatima Q, et al.
The Open Immunology Journal, 13(1), 544-552 (2018)
Verônica Chomiski et al.
Acta cirurgica brasileira, 31(8), 505-512 (2016-09-01)
To evaluate the effect of keratinocyte growth factor (KGF) treatment on the expression of wound-healing-related genes in cultured keratinocytes from burn patients. Keratinocytes were cultured and divided into 4 groups (n=4 in each group): TKB (KGF-treated keratinocytes from burn patients)
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