G3381

Geldanamycin from Streptomyces hygroscopicus

from Streptomyces hygroscopicus, ≥98% (HPLC), Nuclear hormone receptor inhibitor, powder

• Synonym(e): NSC 122750
• Empirische Formel (Hill-System): C₂₉H₄₀N₂O₉
• CAS-Nummer: 30562-34-6
• Molekulargewicht: 560.64
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799914
• NACRES: NA.77
• MDL number: MFCD00274570
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Geldanamycin from Streptomyces hygroscopicus, ≥98% (HPLC), powder
• sterility: non-sterile
• Quality Segment: 300
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: soluble
• antibiotic activity spectrum: neoplastics
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• InChI key: QTQAWLPCGQOSGP-KSRBKZBZSA-N

Beschreibung

General description

Chemical structure: benzenoid

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)