D9500

2′-Deoxyguanosine 5′-monophosphate sodium salt hydrate

≥99% (HPLC)

• Synonym(e): 5′-Deoxyguanylic acid, dGMP
• Empirische Formel (Hill-System): C₁₀H₁₄N₅O₇P · xNa⁺ · yH₂O
• Molekulargewicht: 347.22 (anhydrous free acid basis)
• MDL-Nummer: MFCD00150780
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24894297
• NACRES: NA.51

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥99% (HPLC)
• Form: powder
• Löslichkeit: water: 50 mg/mL, clear, colorless
• Lagertemp.: −20°C
• SMILES String: O.[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP(O)([O-])=O)O3)C(=O)N1
• InChI: 1S/C10H14N5O7P.Na.H2O/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;1H2/q;+1;/p-1/t4-,5+,6+;;/m0../s1
• InChIKey: UVKXYXSKMTUDML-FVALZTRZSA-M

Beschreibung

Anwendung

2′-Deoxyguanosine 5′-monophosphate (dGMP) is used as a substrate of guanylate kinase(s) (EC 2.7.4.8) to form dGDP which upon phosphorylation to dGTP supports DNA biosynthesis. dGMP is use to study physiochemical characteristics of guanine based molecules.

2′-Deoxyguanosine 5′-monophosphate sodium salt hydrate has been used:

• in reversed-phase high pressure liquid chromatography (HPLC) analysis[1]
• to determine the effects of deoxy-mononucleotides on spontaneous proliferating CaCo-2 cell lines[2]
• to determine its capacity to stimulate immune cell growth and function and used influenza virus antigen as an immunostimulant in vitro[3]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3