D9250

2′-Deoxyguanosine 5′-diphosphate sodium salt

≥90% (HPLC), powder

• Synonym(e): dGDP
• Empirische Formel (Hill-System): C₁₀H₁₅N₅O₁₀P₂ · xNa⁺
• CAS-Nummer: 102783-74-4
• Molekulargewicht: 427.20 (free acid basis)
• UNSPSC Code: 41106305
• PubChem Substance ID: 24894274
• NACRES: NA.51
• MDL number: MFCD00057075
• Assay: ≥90% (HPLC)
• Form: powder
• Solubility: water: 50 mg/mL, clear, colorless
• Storage temp.: −20°C

Eigenschaften

• Produktname: 2′-Deoxyguanosine 5′-diphosphate sodium salt, ≥90% (HPLC)
• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: [Na].NC1=NC(=O)c2ncn(C3CC(O)C(COP(O)(=O)OP(O)(O)=O)O3)c2N1
• InChI: 1S/C10H15N5O10P2.Na.H/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20;;/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17);;
• InChI key: VLWIICGGBFZYEZ-UHFFFAOYSA-N

Beschreibung

General description

2′-Deoxyguanosine 5′-diphosphate (dGDP) is a nucleotide with guanine base, deoxyribose and two phosphate.[1]

Application

2′-Deoxyguanosine 5′-diphosphate (dGDP) is used as a substrate of dGDP (nucleoside diphosphate) kinase (2.7.4.6) or pyruvate kinase to produce dGTP in support of DNA biosynthesis. dGDP is used as a substrate to study the kinetics of glycoprotein (gp) 1.7 expressed by bacteriophage T7.

2′-Deoxyguanosine 5′-diphosphate sodium salt has been used as a xanthosine 5′-monophosphate analog and xanthine phosphoribosyl transferase inhibitor in kinetic studies.[2]

Biochem/physiol Actions

2′-Deoxyguanosine 5′-diphosphate (dGDP) inhibits xanthine phosphoribosyl transferase (XPRT) and hypoxanthine-guanine phosphoribosyl transferase (HGPRT).[1]

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves