This product is not tested for RNase activity. Currently, an RNAse tested PMSF product is not available.
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93482
Phenylmethansulfonylfluorid -Lösung
~0.1 M in ethanol (T)
Synonym(e):
Benzylsulfonylfluorid, PMSF
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50 ML
€ 86,00
250 ML
€ 341,00
€ 86,00
Voraussichtliches Versanddatum02. April 2025
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Größe auswählen
Ansicht ändern
50 ML
€ 86,00
250 ML
€ 341,00
About This Item
CAS-Nummer:
Beilstein:
2088311
MDL-Nummer:
UNSPSC-Code:
12352202
PubChem Substanz-ID:
NACRES:
NA.77
€ 86,00
Voraussichtliches Versanddatum02. April 2025
Empfohlene Produkte
Biologische Quelle
microbial
synthetic
Qualitätsniveau
Form
liquid
Konzentration
~0.1 M in ethanol (T)
Dichte
0.797 g/mL at 20 °C
Lagertemp.
2-8°C
SMILES String
FS(=O)(=O)Cc1ccccc1
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChIKey
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Anwendung
Biochem./physiol. Wirkung
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.[4]
Phenylmethanesulfonyl fluoride (PMSF) is a serine protease inhibitor. It binds covalently to active site residue of proteases and prevents proteolytic activity. PMSF is used in cell lysate buffers during protein purification to prevent target protein degradation.[5] PMSF effectively inhibits the naloxone-precipitated withdrawal jumping.[6]
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
Lagerklassenschlüssel
3 - Flammable liquids
WGK
WGK 2
Flammpunkt (°F)
53.6 °F - closed cup
Flammpunkt (°C)
12 °C - closed cup
Persönliche Schutzausrüstung
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Zulassungslistungen
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EU REACH Annex XVII (Restriction List)
CAS No.
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Intraperitoneal (IP) injection of the serine proteinase inhibitor phenylmethylsulfonyl fluoride (PMSF) produced dose-dependent analgesia in Sprague-Dawley rats. AD50 was 2.9 +/- 1.4 (S.E.) mg kg-1, the analgesia was antagonized by naloxone but unaffected by atropine. PMSF significantly enhanced the analgesic
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We have designed and synthesized novel irreversible serine protease inhibitors containing aliphatic sulfonyl fluorides as an electrophilic trap. These substituted taurine sulfonyl fluorides derived from taurine or protected amino acids were conveniently synthesized from β-aminoethanesulfonyl chlorides using KF/18-crown-6 or from
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Is this product 93482 RNase-free?
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How can I further dilute Product 93482, Phenylmethanesulfonyl fluoride solution?
1 answer-
We would recommend that you use an anhydrous ethanol to further dilute this solution, since PMSF is very unstable in water.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can Product 93482, Phenylmethanesulfonyl fluoride solution, be used for?
1 answer-
PMSF is a serine protease inhibitor, inhibiting the activity of enzymes such as thrombin, trypsin, papain, chymotrypsin and proteinase K. It also inhibits mammalian acetylcholinesterases.
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