Glycochenodeoxycholsäure Natriumsalz

Name: Glycochenodeoxycholsäure Natriumsalz
Brand: SIGMA
Price: 552 EUR

≥97.0% (TLC)

Synonym(e):

3α,7α-Dihydroxy-5β-cholanonsäure N-(carboxymethyl)amid Natriumsalz, N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycin Natriumsalz, Natriumglycochendesoxycholat

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₆H₄₂NNaO₅

CAS-Nummer:

16564-43-5

Molekulargewicht:

471.61

UNSPSC Code:

12161902

NACRES:

NA.77

PubChem Substance ID:

329757607

MDL number:

MFCD00036743

Beilstein/REAXYS Number:

3847290

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InChI

1S/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1

SMILES string

[Na+].C[C@H](CCC(=O)NCC([O-])=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI key

AAYACJGHNRIFCT-YRJJIGPTSA-M

description

anionic

assay

≥97.0% (TLC)

form

powder

mol wt

471.61 g/mol

technique(s)

protein quantification: suitable

solubility

H₂O: 50 mg/mL, clear, faintly yellow

functional group

amide

Quality Level

100

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Dieser Artikel	30970	G9910	D5670
Sigma-Aldrich 50534 Sodium glycochenodeoxycholate	Sigma-Aldrich 30970 Sodium deoxycholate	Sigma-Aldrich G9910 Sodium glycodeoxycholate	Sigma-Aldrich D5670 Sodium deoxycholate monohydrate
technique(s) protein quantification: suitable	technique(s) DNA purification: suitable, RNA purification: suitable, electrophoresis: suitable	technique(s) -	technique(s) electrophoresis: suitable, immunoprecipitation (IP): suitable
assay ≥97.0% (TLC)	assay ≥98.0% (dry matter, NT)	assay ≥97% (HPLC)	assay ≥99.0% (titration)
form powder	form powder	form -	form powder
mol wt 471.61 g/mol	mol wt micellar avg mol wt 1200-5000	mol wt 471.61 g/mol	mol wt 432.57 g/mol
description anionic	description anionic	description anionic	description anionic
Quality Level 100	Quality Level 300	Quality Level 200	Quality Level 200

Other Notes

Studies on cholesterol solubilizing capacities[1]

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.

H Higuchi et al.

The Journal of biological chemistry, 276(42), 38610-38618 (2001-08-17)

Toxic bile salts induce hepatocyte apoptosis by both Fas-dependent and -independent mechanisms. In this study, we examined the cellular mechanisms responsible for Fas-independent, bile acid-mediated apoptosis. HuH-7 cells, which are known to be Fas deficient, were stably transfected with the

Thermodynamic and molecular basis for dissimilar cholesterol-solubilizing capacities by micellar solutions of bile salts: cases of sodium chenodeoxycholate and sodium ursodeoxycholate and their glycine and taurine conjugates.

M C Carey et al.

Biochemistry, 20(12), 3637-3648 (1981-06-09)

The bile salts chenodeoxycholate (CDC) and its 7 beta-hydroxy epimer ursodeoxycholate (UDC) are administered therapeutically (as acids) to dissolve cholesterol gallstones in man. Since their micellarr solutions and those of their physiological conjugates differ strikingly in their capacities to solubilize

Nitric oxide mimics transcriptional and post-translational regulation during α-tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes.

Raúl González et al.

Journal of hepatology, 55(1), 133-144 (2010-12-15)

Reactive oxygen species (ROS) and nitric oxide (NO) exert a relevant role during bile acid-induced hepatotoxicity. Whether α-Tocopherol regulates oxidative and nitrosative stress, bile acid transporter expression and their NO-dependent post-translational modifications, and cell death were assessed in vitro and

Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer.

Bodvaël Pennarun et al.

Biochimica et biophysica acta, 1805(2), 123-140 (2009-12-08)

Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2. Primary components of the DISC are

iNOS/NO signaling regulates apoptosis induced by glycochenodeoxycholate in hepatocytes.

Kewei Wang et al.

Cellular signalling, 23(10), 1677-1685 (2011-06-23)

Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) can ameliorate apoptosis induced by toxic glycochenodeoxycholate (GCDC) in hepatocytes. However, the underlying molecular mechanisms are not yet understood in detail. This study is to clarify the function of iNOS/NO and

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Glycochenodeoxycholsäure Natriumsalz