RDD043

Acetylcholinchlorid

≥99% (TLC), free-flowing, Redi-Dri^™

• Synonym(e): 2-Acetoxyethyltrimethylammonium chloride, Trimethyl(2-acetoxyethyl)ammonium chloride, ACh
• Lineare Formel: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS-Nummer: 60-31-1
• Molekulargewicht: 181.66
• NACRES: NA.25
• UNSPSC Code: 51151535
• Beilstein/REAXYS Number: 3571875
• MDL number: MFCD00011698

Eigenschaften

• product line: Redi-Dri^™
• Quality Segment: 100
• assay: ≥99% (TLC)
• form: powder
• quality: free-flowing
• packaging: pkg of 100 g
• color: white to faint yellow cast
• mp: 146-150 °C (lit.)
• solubility: H₂O: 100 mg/mL
• density: 1.27 g/cm³
• storage temp.: room temp
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M

Beschreibung

General description

Acetylcholine Chloride, the chloride salt of acetylcholine, is a synthetic amino alcohol with cholinergic properties, making it a vital component in biochemical and neurotransmission studies. It replicates the effects of the endogenous acetylcholine compound, which plays a significant role in the immune system, inflammation, and allergy research. Acetylcholine chloride acts as a cholinergic neurotransmitter, binding to nicotinic and muscarinic acetylcholine receptors, facilitating the opening of calcium channels.Furthermore, Acetylcholine chloride (ACh chloride) functions as a potent cholinergic agonist, influencing the activity of dopaminergic (DAergic) neurons by stimulating nicotinic acetylcholine receptors (nAChRs). This feature is particularly relevant in studies related to the immune system and inflammation. Additionally, it demonstrates the capacity to inhibit the aggregation of p53 mutant peptide in vitro, which contributes to the exploration of biochemical and allergy research.

Application

Acetylcholine chloride has been used:

• as an agent to trigger sudomotor axon reflex response during autonomic test
• to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
• as a substrate for acetylcholinesterase
• to stimulate after discharge in Aplysia bag cell neurons

Biochem/physiol Actions

Acetylcholinchlorid, injiziert in einer Dosis von 20 mg/kg Körpergewicht, reduziert die Mortalität und die proinflammatorischen Plasma-Zytokine bei Mäusen mit experimentell induzierter Sepsis . Der cholinerge entzündungshemmende Mechanismus wird wahrscheinlich durch die Interaktion von Acetylcholin mit dem α7n-Cholinrezeptor auf Monozyten, Makrophagen und Neutrophilen vermittelt, wodurch die Spiegel proinflammatorischer Zytokine wie TNF-α, IL-1β und IL-6 gesenkt werden.

Endogener Neurotransmitter in cholinergenen Synapsen; verstärkt das Aktionspotential am Sarcolemma und ruft dadurch Muskelkontraktionen hervor.

Features and Benefits

• Redi-Dri^™ format for Improved Efficiency and Time Savings
• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Other Notes

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Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Disclaimer

Very hygroscopic

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable