A9101

Acetylcholinchlorid

≥99% (TLC), powder or crystals

• Synonym(e): ACh
• Lineare Formel: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS-Nummer: 60-31-1
• Molekulargewicht: 181.66
• NACRES: NA.32
• PubChem Substance ID: 57653883
• UNSPSC Code: 12352204
• EC Number: 200-468-8
• MDL number: MFCD00011698
• Beilstein/REAXYS Number: 3571875
• eCl@ss: 32190102

Eigenschaften

• Produktname: Acetylcholinchlorid, pkg of 150 mg (per vial)
• assay: ≥99% (TLC)
• Quality Segment: 100
• form: powder or crystals
• packaging: pkg of 150 mg (per vial)
• mp: 146-150 °C (lit.)
• solubility: H₂O: soluble
• storage temp.: room temp
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M
• Gene Information: human ... CHRM3(1131)

Beschreibung

General description

Acetylcholine is an important neurotransmitter that plays a critical role in multiple neurological systems. Crucial for neurobiology studies, acetylcholine aids researchers in understanding synaptic transmission. In other forms of research, acetylcholine has an effect and influence on tumor neurobiology for cancer R&D, as well as a variety of other cognitive processes.

Application

For use as a substrate to determine acetylcholinesterase activity. Acetylcholine chloride has been used:

• for standard curve preparation in hestrin assay
• in Protein expression, radioactive ligand binding assay and electrophysiological studies of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBPs)
• as a supplement in extracellular solutions for treating the voltage clamped cells in electrophysiology studies

Biochem/physiol Actions

Acetyl choline (ACh) is an essential neurotransmitter in both central and peripheral nervous system. ACh binds to nicotinic acetylcholine receptors (nAChRs) and causes fast excitatory neurotransmission.

Acetylcholinchlorid, injiziert in einer Dosis von 20 mg/kg Körpergewicht, reduziert die Mortalität und die proinflammatorischen Plasma-Zytokine bei Mäusen mit experimentell induzierter Sepsis . Der cholinerge entzündungshemmende Mechanismus wird wahrscheinlich durch die Interaktion von Acetylcholin mit dem α7n-Cholinrezeptor auf Monozyten, Makrophagen und Neutrophilen vermittelt, wodurch die Spiegel proinflammatorischer Zytokine wie TNF-α, IL-1β und IL-6 gesenkt werden.

Endogener Neurotransmitter in cholinergenen Synapsen; verstärkt das Aktionspotential am Sarcolemma und ruft dadurch Muskelkontraktionen hervor.

Preparation Note

Reconstituted solution is stable for 2 weeks when stored at 2-8 °C

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves