1008501

Acetylcholinchlorid

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): ACh
• Lineare Formel: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS-Nummer: 60-31-1
• Molekulargewicht: 181.66
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329748884
• MDL number: MFCD00011698
• Beilstein/REAXYS Number: 3571875

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: acetylcholine
• manufacturer/tradename: USP
• mp: 146-150 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M
• Gene Information: human ... CHRM3(1131)

Beschreibung

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetylcholine chloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

• Acetylcholine Chloride for Ophthalmic Solution
• Methacholine Chloride

Biochem/physiol Actions

Acetylcholinchlorid, injiziert in einer Dosis von 20 mg/kg Körpergewicht, reduziert die Mortalität und die proinflammatorischen Plasma-Zytokine bei Mäusen mit experimentell induzierter Sepsis . Der cholinerge entzündungshemmende Mechanismus wird wahrscheinlich durch die Interaktion von Acetylcholin mit dem α7n-Cholinrezeptor auf Monozyten, Makrophagen und Neutrophilen vermittelt, wodurch die Spiegel proinflammatorischer Zytokine wie TNF-α, IL-1β und IL-6 gesenkt werden.

Endogener Neurotransmitter in cholinergenen Synapsen; verstärkt das Aktionspotential am Sarcolemma und ruft dadurch Muskelkontraktionen hervor.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable