PHR1393

Ampicillin-Trihydrat

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): Ampicillin Trihydrat, D-(−)-α-Aminobenzylpenicillin
• Empirische Formel (Hill-System): C₁₆H₁₉N₃O₄S · 3H₂O
• CAS-Nummer: 7177-48-2
• Molekulargewicht: 403.45
• Beilstein: 5399534
• EG-Nummer: 200-709-7
• MDL-Nummer: MFCD00072036
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823367
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to BP 785; traceable to Ph. Eur. A1000000; traceable to USP 1033000/1033407
• API-Familie: ampicillin
• Analysenzertifikat (CofA): current certificate can be downloaded
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• mp (Schmelzpunkt): 198-200 °C (dec.) (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(O)=O
• InChI: 1S/C16H19N3O4S.3H2O/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);3*1H2/t9-,10-,11+,14-;;;/m1.../s1
• InChIKey: RXDALBZNGVATNY-CWLIKTDRSA-N

Beschreibung

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Ampicillin trihydrate may be used as an analytical reference standard for the determination of ampicillin in plasma samples and pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Ein ß-Lactam-Antibiotikum mit Aminogruppen-Seitenkette an der Penicillinstruktur. Penicillin-Derivat das die bakterielle Zellwandsynthese (Peptidoglycan-Vernetzung) hemmt, indem Transpeptidasen an der inneren Oberfläche der bakteriellen Zellmembranen inaktiviert werden. Bacterizid nur für wachsende Escherichia coli . Art der Resistenz: Spaltung des β-Lactamrings des Ampicillin durch β-Lactamase. Antimikrobielles Spektrum: Gram-negative und Gram-positive Bakterien.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA1900 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H315,H317,H319,H334,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable