Methods and findings in experimental and clinical pharmacology, 11(4), 235-239 (1989-04-01)
The effects of four nootropic drugs (piracetam, aniracetam, meclofenoxate and fipexide) on cognitive functions impaired by the antihypertensive drug clonidine were investigated in albino rats. The changes in learning and memory were studied by two-way active avoidance with punishment reinforcement
Current medical research and opinion, 10(2), 99-106 (1986-01-01)
Forty geriatric in-patients with severe cognition disorders were randomly allocated to treatment with either 600 mg fipexide daily or placebo over a period of 3 weeks. Before and after treatment, the symptoms of cognitive performance (disorders of memory and attention
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 804(2), 337-343 (2004-04-15)
Qualitative studies are described on the metabolism and the toxicological analysis of the nootropic fipexide (FIP) in rat urine using gas chromatography-mass spectrometry (GC-MS). FIP was extensively metabolized to 1-(3,4-methylenedioxybenzyl)piperazine (MDBP), 4-chlorophenoxyacetic acid, 1-[2-(4-chlorophenoxy)acetyl]piperazine, N-(4-hydroxy-3-methoxy-benzyl)piperazine, piperazine, N-(3,4-methylenedioxybenzyl)ethylenediamine, and N-[2-(4-chlorophenoxy)acetyl]ethylenediamine. The
A selective and sensitive approach, called extraction of product ion (XoPI) method, was developed for the detection of l-glutathione (GSH)-trapped reactive metabolites employing an Orbitrap high resolution mass spectrometer. Fragmentation of GSH conjugates in the negative ion mode leads to
Methods and findings in experimental and clinical pharmacology, 8(6), 337-341 (1986-06-01)
According to the two preceding papers, the possible difference in activity of brain stimulants on memory retrieval of "good" and "poor" learning mice was studied. Among the drugs studied, caffeine, oxiracetam and nicotine significantly improved memory recall of poor learning
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