76899

Temozolomid

VETRANAL^®, analytical standard

• Synonym(e): 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-8-carboxamid, 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazincarboxamid, 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-trien-9-carboxamid, 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-on, NSC 362856
• Empirische Formel (Hill-System): C₆H₆N₆O₂
• CAS-Nummer: 85622-93-1
• Molekulargewicht: 194.15
• MDL-Nummer: MFCD00866492
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329767423
• NACRES: NA.24

Eigenschaften

• Qualität: analytical standard
• Qualitätsniveau: 100
• Produktlinie: VETRANAL^®
• Assay: ≥99.0% (HPLC)
• Haltbarkeit: limited shelf life, expiry date on the label
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Glührückstand: ≤0.2%
• Verlust: ≤0.5% loss on drying
• Anwendung(en): forensics and toxicology; pharmaceutical (small molecule); veterinary
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: CN1N=Nc2c(ncn2C1=O)C(N)=O
• InChI: 1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
• InChIKey: BPEGJWRSRHCHSN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Temozolomide (TMZ) is an alkylating agent of the imidazotetrazine derivatives that shows broad-spectrum antitumor activity against murine tumors.

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

TMZ may be used as a reference standard for the analysis of temozolomide in serum and brain tumor samples by micellar electrokinetic capillary chromatography (MEKC), in aqueous solutions by liquid chromatography-electrospray-tandem mass spectrometry (LC-ESI-MS/MS), in active pharmaceutical ingredients (APIs) by high performance liquid chromatography (HPLC) with MS/MS and in pharmaceutical dosage form by HPLC equipped with photodiode array (PDA) detector.

Rechtliche Hinweise

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H315,H319,H335,H340,H350,H360FD
• P-Sätze: P201 - P202 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges