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49432
Pyridin-3-sulfonylchlorid
for HPLC derivatization, LiChropur™, ≥98.0% (GC)
Synonym(e):
3-Pyridinsulfonylchlorid, 3-Pyridylsulfonylchlorid
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About This Item
Empirische Formel (Hill-System):
C5H4ClNO2S
Molekulargewicht:
177.61
Beilstein:
120820
MDL-Nummer:
UNSPSC-Code:
12352200
Empfohlene Produkte
Qualität
for HPLC derivatization
LiChropur™
Qualitätsniveau
Assay
≥98.0% (GC)
97.0-103.0% (AT)
Methode(n)
HPLC: suitable
Lagertemp.
2-8°C
SMILES String
O=S(C1=CC=CN=C1)(Cl)=O
Allgemeine Beschreibung
Pyridine-3-sulfonyl chloride belongs to the class of substituted sulfonyl chlorides, which can be used as derivatization agents owing to their high proton affinity.[1]
Anwendung
Pyridine-3-sulfonyl chloride may be used as a derivatization agent to enhance the sensitivity of metabolites formed during the incubation of cytochrome P450 isoforms in aqueous medium,[2] steroidal estrogens in biological samples,[1] and bisphenols in beverages[3] for their subsequent determination by high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).
Rechtliche Hinweise
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flammpunkt (°F)
No data available
Flammpunkt (°C)
No data available
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In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography-tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment
De Bock L, et al.
Journal of Chromatography A, 1218(6), 793-801 (2011)
Determination of bisphenols in beverages by mixed-mode solid-phase extraction and liquid chromatography coupled to tandem mass spectrometry
Regueiro J and Wenzl T
Journal of Chromatography A, 1422(1), 230-238 (2015)
Li Xu et al.
Analytical biochemistry, 375(1), 105-114 (2007-12-29)
Sulfonyl chlorides substituted with functional groups having high proton affinity can serve as derivatization reagents to enhance the sensitivity for steroidal estrogens in liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The most commonly used reagent for derivatization of estrogens
Chemical derivatization to enhance ionization of anabolic steroids in LC-MS for doping-control analysis.
Athanasiadou, I., et al.
Trends in Analytical Chemistry, 42, 137-156 (2013)
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