662057
Ubiquitin, GST-Fusion, Recombinant, E. coli
Synonym(e):
GST-Ub, no change
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1 MG
€ 406,00
€ 406,00
Voraussichtliches Versanddatum28. Mai 2025
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1 MG
€ 406,00
About This Item
UNSPSC-Code:
12352202
NACRES:
NA.77
€ 406,00
Voraussichtliches Versanddatum28. Mai 2025
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Allgemeine Beschreibung
Research area: Cancer
Recombinant ubiquitin fused at the N-terminus to GST and expressed in E. coli. Useful for glutathione affinity purification of ubiquitinated molecules. Can also be used for immunodetection of conjugates using GST antibodies. Facilitates the visualization of polyUb chains due to larger ladder intervals.
Recombinant ubiquitin fused at the N-terminus to GST and expressed in E. coli. Useful for glutathione affinity purification of ubiquitinated molecules. Can also be used for immunodetection of conjugates using GST antibodies. Facilitates the visualization of polyUb chains due to larger ladder intervals.
Anwendung
Biochem./physiol. Wirkung
The ubiquitin (Ub) system plays a crucial role in protein homeostasis by maintaining protein balance in pathways related to DNA repair, cell cycle progression, apoptosis (programmed cell death), receptor-mediated endocytosis, and signal transduction. Imbalances or dysfunctions within this system can lead to pathological conditions.[3] Apart from this, disruptions in ubiquitin pathways can also contribute to the development of human diseases, including neurodegenerative conditions and tumors.[4][5]
Verpackung
Please refer to vial label for lot-specific concentration.
Warnhinweis
Toxicity: Standard Handling (A)
Physikalische Form
In 100 mM NaCl, 50 mM HEPES, pH 8.0.
Rekonstituierung
Following initial thaw, aliquot and freeze (-70°C).
Rechtliche Hinweise
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases
Munoz ET, et al.
Abstr. Soc. Neurosci (2017)
Ubiquitin
Kona F.R, et al.
Brenner and Rector's The Kidney E-book, 242-245 (2013)
Ubiquitin networks in cancer
Kirkin V and Dikic I
Current Opinion in Genetics & Development, 21(1), 21-28 (2011)
Mengmeng Niu et al.
PLoS biology, 19(2), e3001113-e3001113 (2021-02-25)
Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion program
Mengmeng Niu et al.
Nature communications, 12(1), 5919-5919 (2021-10-13)
Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase inhibitors (TKIs) is a major hurdle for NSCLC treatment. Here, we show that F-box protein FBXL2 targets EGFR and EGFR
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