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RHC-80267

Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells.

Synonym(e):

RHC-80267, 1,6- bis(Cyclohexyloximinocarbonylamino)hexane

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Größe/SKUVerfügbarkeitPreis
10 mg
Warenkorb auf Verfügbarkeit prüfen
€ 134,00

Über diesen Artikel

Empirische Formel (Hill-System):
C20H34N4O4
CAS-Nummer:
Molekulargewicht:
394.51
NACRES:
NA.77
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze

€ 134,00


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Quality Segment

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

DMSO: 25 mg/mL, ethanol: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)

InChI key

RXSVYGIGWRDVQC-UHFFFAOYSA-N

General description

Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biochem/physiol Actions

Cell permeable: no
Primary Target
DAG lipase
Product does not compete with ATP.
Reversible: no
Target IC50: 4 nM against DAG lipase activity in canine platelets

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Dieser Artikel
287891R2028361551
description

Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells.

description

A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 µM).

description

≥98% (HPLC), solid

description

The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

storage temp.

10-30°C

storage temp.

10-30°C

storage temp.

-

storage temp.

2-8°C

solubility

ethanol: 25 mg/mL, DMSO: 25 mg/mL

solubility

ethanol: 3 mg/mL, DMSO: 3 mg/mL

solubility

DMSO: 9 mg/mL

solubility

DMSO: 10 mg/mL


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Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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