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810251P

Avanti

NBD-6 Cholesterol

Avanti Research™ - A Croda Brand 810251P, powder

Synonym(e):

5-cholesten-3β-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]caproate

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About This Item

Empirische Formel (Hill-System):
C39H58N4O5
CAS-Nummer:
201731-19-3
Molekulargewicht:
662.90
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (810251P-1mg)
pkg of 1 × 5 mg (810251P-5MG)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 810251P

Versandbedingung

dry ice

Lagertemp.

−20°C

Verwandte Kategorien

Allgemeine Beschreibung

NBD-6 Cholesterol is a fluorescent analog of the lipoprotein compound cholesterol, with NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) being the fluorescent group.

Anwendung

NBD-6 Cholesterol has been used for NBD-cholesterol binding assay, to study the binding of fluorescent NBD cholesterol in the binding pocket concerning ASTER domains.

Biochem./physiol. Wirkung

Cholesterol is produced from acetyl-CoA by a complex multistep mevalonate pathway. In mammals, liver is the main site of de novo cholesterol synthesis contributing to almost 80% of total cholesterol synthesis. Cholesterol and its metabolites, along with its precursors, play important roles in cellular membrane physiology. They also have roles in reproductive biology, dietary nutrient absorption, stress responses, salt and water balance and calcium metabolism.

Verpackung

5 mL Amber Glass Screw Cap Vial (810299P-1MG)
5 mL Amber Glass Screw Cap Vial (810251P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

No data available

Flammpunkt (°C)

No data available

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

SAE0087

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Fluorescent and Luminescent Probes for Biological Activity (1999)
Molecular Nutrition And Food Research, 277-290 (2016)
Cholesterol in health and disease.
Ira Tabas
The Journal of clinical investigation, 110(5), 583-590 (2002-09-05)
Pedro M R Cruz et al.
Frontiers in pharmacology, 4, 119-119 (2013-10-05)
While the unique metabolic activities of malignant tissues as potential targets for cancer therapeutics has been the subject of several recent reviews, the role of cholesterol metabolism in this context is yet to be fully explored. Cholesterol is an essential
Jaspreet Sandhu et al.
Cell, 175(2), 514-529 (2018-09-18)
The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here, we describe three ER-resident proteins (Aster-A, -B, -C) that

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