700042P

4β-hydroxycholesterol-d7

Avanti Research^™ - A Croda Brand

• Synonym(e): cholest-5-ene-3b,4b-diol(d7)
• Empirische Formel (Hill-System): C₂₇H₃₉O₂D₇
• CAS-Nummer: 1246302-80-6
• Molekulargewicht: 409.70
• MDL-Nummer: MFCD15071187
• UNSPSC-Code: 12352100
• NACRES: NA.25

Eigenschaften

• Beschreibung: cholest-5-ene-3,4-diol-d7
• Assay: >99% (TLC)
• Form: powder
• Verpackung: pkg of 1 × 1 mg (700042P-1mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: O[C@@H]1[C@@H](C2=CC[C@H]3[C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)(CC[C@@H]3[C@]2(CC1)C)C)O
• InChI: 1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D
• InChIKey: CZDKQKOAHAICSF-BZNWTYAPSA-N

Beschreibung

Allgemeine Beschreibung

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4).[1] 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

Anwendung

4β-hydroxycholesterol-d7 has been used:

• as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis[1]
• to spike serum samples for mass spectrometry measurements[2]
• as an internal standard for the quantification of human colon biopsies samples using HPLC-MS[3]

Biochem./physiol. Wirkung

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand.[3] The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.[3]

Verpackung

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids