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H125
Harmalol -hydrochlorid Dihydrat
monoamine oxidase inhibitor
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About This Item
Empirische Formel (Hill-System):
C12H12N2O · HCl · 2H2O
CAS-Nummer:
Molekulargewicht:
272.73
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
Empfohlene Produkte
Arzneimittelkontrolle
regulated under CDSA - not available from Sigma-Aldrich Canada
mp (Schmelzpunkt)
264-267 °C (dec.) (lit.)
SMILES String
Cl[H].[H]O[H].[H]O[H].CC1=NCCc2c1[nH]c3cc(O)ccc23
InChI
1S/C12H12N2O.ClH.2H2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12;;;/h2-3,6,14-15H,4-5H2,1H3;1H;2*1H2
InChIKey
OYKGNQNESCZSHQ-UHFFFAOYSA-N
Biochem./physiol. Wirkung
Harmalol, a harmala (β-carboline) alkaloid, is a monoamine oxidase inhibitor (MAOi) useful for studies involving melanogenesis. Harmalol is use in β-carboline nucleic acid (DNA and RNA) binding studies.
Lagerklassenschlüssel
13 - Non Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Ji-Hyun Im et al.
Vascular pharmacology, 50(5-6), 147-152 (2008-12-17)
Beta-carboline alkaloids including harmalol, harmaline, norharmane, harmol, harmine and harmane are important constituents of the medicinal plant, Perganum harmala L. (Zygophylaceae), which has been used in traditional medicine. In the present study, the antiplatelet activities of six beta-carboline alkaloid compounds
C C Shi et al.
Japanese journal of pharmacology, 85(3), 299-305 (2001-04-28)
Three psychological active principles from the seeds of Peganum harmala L., harmine, harmaline and harmalol, showed vasorelaxant activities in isolated rat thoracic aorta preparations precontracted by phenylephrine or KCl with rank order of relaxation potency of harmine > harmaline >
Najma Arshad et al.
Phytotherapy research : PTR, 22(11), 1533-1538 (2008-09-25)
In the present study the antimicrobial potential of various extracts from 12 medicinal plants has been investigated in vitro on multiple antibiotic resistant pathogens and some selected protozoa isolated from poultry. The initial examination was performed on E. coli (n
M Kartal et al.
Journal of pharmaceutical and biomedical analysis, 31(2), 263-269 (2003-03-01)
A simple and sensitive method for separation and determination of harmol, harmalol, harmine and harmaline has been developed and validated. Harmol, harmalol, harmine and harmaline were separated using a Metasil ODS column by isocratic elution with flow rate 1.5 ml/min.
D H Kim et al.
The European journal of neuroscience, 13(10), 1861-1872 (2001-06-14)
The present study elucidated the protective effect of beta-carbolines (harmaline, harmalol and harmine) against oxidative damage of brain mitochondria, synaptosomes and PC12 cells induced by either dopamine or 6-hydroxydopamine. Harmaline, harmalol and antioxidant enzymes (superoxide dismutase/SOD and catalase) decreased the
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