926248

Redox Responsive Poly(ethylene glycol)-block-poly(lactide-alt-glycolide)

PEG average M_n 5000, PLGA M_n 15000

• Synonym(e): Drug release, PEG-PLGA with disulfide linkage, PEG-SS-PLGA, Stimuli-responsive
• Lineare Formel: CH₃O(C₂H₄O)_nC₇H₁₂O₄S₂(C₅H₆O₄)_m
• UNSPSC-Code: 12352112
• NACRES: NA.23

Eigenschaften

• Form: powder, chunks or granules
• Qualitätsniveau: 100
• Mol-Gew.: PEG average M_n 5000; PLGA M_n 15000
• Lagertemp.: 2-8°C
• SMILES String: O=C(C(C)OC(CO[H])=O)OCCSSCCOC(OCCOCCOC)=O
• InChI: 1S/C15H26O10S2/c1-12(25-13(17)11-16)14(18)22-7-9-26-27-10-8-24-15(19)23-6-5-21-4-3-20-2/h12,16H,3-11H2,1-2H3
• InChIKey: DPMVWUUTGXWXPV-UHFFFAOYSA-N

Beschreibung

Anwendung

PEG-SS-PLGA is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(lactide-alternative-glycolide) (PLGA) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.

Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.

Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable