808598

CLAmP

• Synonym(e): N-Methoxy-N-methyl-1H-pyrrole-1-carboxamide, Heller-Sarpong Reagent
• Empirische Formel (Hill-System): C₇H₁₀N₂O₂
• Molekulargewicht: 154.17
• UNSPSC-Code: 12352000
• PubChem Substanz-ID: 329769111

Eigenschaften

• Form: liquid
• Brechungsindex: n/D 1.510
• Dichte: 1.126 g/mL
• Lagertemp.: 2-8°C
• SMILES String: O=C(N(OC)C)N1C=CC=C1
• InChI: 1S/C7H10N2O2/c1-8(11-2)7(10)9-5-3-4-6-9/h3-6H,1-2H3
• InChIKey: NLSJGNBOCVXWHS-UHFFFAOYSA-N

Beschreibung

Anwendung

The CLAmP (Carbonyl Linchpin N, O-dimethylhydroxylamine pyrrole) reagent, reported by Sarpong and Heller, is a useful building block for the efficient synthesis of unsymmetrical ketones. CLAmP shows high versatility based on compatibility with both highly reactive, thermally unstable nucleophiles as well as less reactive stable nucleophiles. It reacts with Grignard reagents to form the corresponding Weinreb amides.[1]

Sonstige Hinweise

One-pot Unsymmetrical Ketone Synthesis Employing a Pyrrole-Bearing Formal Carbonyl Dication Linchpin Reagent

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): 230.0 °F
• Flammpunkt (°C): 110 °C