808490

N⁶-Propargyl-ATP sodium salt

• Synonym(e): (N⁶pATP) sodium salt, N⁶-Propargyl-adenosine-5’-triphosphate sodium salt
• Empirische Formel (Hill-System): C₁₃H₁₈N₅O₁₃P₃ · xNa⁺
• Molekulargewicht: 545.23 (free acid basis)
• UNSPSC Code: 12352106
• PubChem Substance ID: 329769102
• NACRES: NA.22

Eigenschaften

• assay: ≥95% (HPLC)
• Quality Segment: 200
• form: solid
• reaction suitability: reaction type: click chemistry
• solubility: 10 mM Tris-HCl, pH 7.5: soluble
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O[C@@H]([C@H]1O)[C@@H](COP(O)(OP(O)(OP(O)(O)=O)=O)=O)O[C@@H]1N2C=NC3=C2N=CN=C3NCC#C
• InChI: 1S/C13H18N5O13P3/c1-2-3-14-11-8-12(16-5-15-11)18(6-17-8)13-10(20)9(19)7(29-13)4-28-33(24,25)31-34(26,27)30-32(21,22)23/h1,5-7,9-10,13,19-20H,3-4H2,(H,24,25)(H,26,27)(H,14,15,16)(H2,21,22,23)/t7-,9-,10-,13?/m1/s1
• InChI key: MUOIWXPACQCYQC-RJNFYWFKSA-N

Beschreibung

Application

N⁶-Propargyl-ATP is suitable for in vitro AMPylation of proteins as well as in vitro polyadenylation of RNA. The resulting alkyne-functionalized protein or RNA can be processed using Cu(I)-catalyzed click chemistry to attach azide-labeled molecules. This gives options such as introduction of a biotin group for purification tasks, introduction of a fluorescent group for detection, or crosslinking to other azide-functionalized biomolecules.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable