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Sigma-Aldrich

Phosgen -Lösung

~20% in toluene

Synonym(e):

Carbon oxychloride, Carbonyl chloride, Phosgen

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About This Item

Lineare Formel:
COCl2
CAS-Nummer:
75-44-5
Molekulargewicht:
98.92
Beilstein:
1098367
MDL-Nummer:
MFCD00036119
UNSPSC-Code:
12352101
PubChem Substanz-ID:
57652789
NACRES:
NA.22

Form

solution

Qualitätsniveau

200

Eignung der Reaktion

reaction type: Carbonylations

Konzentration

~20% in toluene

Verunreinigungen

≤300 mg/kg benzene

Lagertemp.

2-8°C

SMILES String

ClC(Cl)=O

InChI

1S/CCl2O/c2-1(3)4

InChIKey

YGYAWVDWMABLBF-UHFFFAOYSA-N

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Allgemeine Beschreibung

Phosgene is an organic chemical compound widely used as a chlorinating agent, carbonylating agent, and dehydrating agent in organic synthesis for the synthesis of various compounds.

Anwendung

Phosgene solution (~20% in toluene) can be used as a reagent in the synthesis of multiblock copolymers via multiple coupling reactions. It is also used in the activation of the hydroxyl groups in poly(ethylene glycol) diol (PEG diol) to synthesize linear multifunctional poly(ethylene glycol).

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT SE 1 Inhalation - STOT SE 3

Zielorgane

Central nervous system, Lungs

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 3

Flammpunkt (°F)

39.2 °F - closed cup

Flammpunkt (°C)

4 °C - closed cup

Persönliche Schutzausrüstung

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Analysenzertifikate (COA)

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Wenli Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 131(2), 612-628 (2012-11-13)
Phosgene gas is a lower respiratory tract irritant. As such, it stimulates nociceptive vagal C-fiber-related reflexes in a dose-rate and concentration × exposure duration (C × t)-dependent manner. In rats, this reflex is characterized by extended apnea time periods, bradycardia
Wen-Li Li et al.
Inhalation toxicology, 23(13), 842-852 (2011-11-01)
The principal acute mode of action of inhaled phosgene gas is related to an increase alveolar fluid exudation under pathologic conditions. This paper considers some aspects in modeling phosgene-induced acute lung injury (ALI) in an acute rat bioassay and whether
Hong-li Chen et al.
Journal of applied toxicology : JAT, 33(1), 71-77 (2011-08-06)
Phosgene is a poorly water-soluble gas penetrating the lower respiratory tract which can induce acute lung injury characterized by a latent phase of fatal pulmonary edema. Pulmonary edema caused by phosgene is believed to be a consequence of oxidative stress
J P Wyatt et al.
Journal of accident & emergency medicine, 12(3), 212-213 (1995-09-01)
Phosgene is a highly toxic gas to which some workers may be occupationally exposed. This case report demonstrates the possibility of refrigeration workers suffering phosgene poisoning after heating certain chlorinated fluorocarbons ('freons'). The need to suspect phosgene exposure and observe
O Gyllenhaal et al.
Journal of chromatography, 435(2), 259-269 (1988-01-08)
The use of phosgene as a derivatizing agent for bifunctional compounds prior to gas and liquid chromatographic analysis is reviewed. Applications include gas chromatographic determinations of metoprolol and its metabolites in biological fluids, enantiomeric separations of beta-blocking drugs and sympathomimetic
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