790435

TCO PEG4 succinimidyl ester

• Synonym(e): trans-Cyclooctene-PEG4-NHS
• Empirische Formel (Hill-System): C₂₄H₃₈N₂O₁₀
• Molekulargewicht: 514.57
• MDL-Nummer: MFCD28118912
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 329768214
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Eignung der Reaktion: reaction type: click chemistry; reagent type: linker
• Funktionelle Gruppe: NHS ester
• Lagertemp.: −20°C
• SMILES String: O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)OC2CCC/C=C/CC2
• InChI: 1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1+
• InChIKey: ZKPMRASGLDBKPF-OWOJBTEDSA-N

Beschreibung

Anwendung

Succinimidyl ester/NHS (amine reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted, copper-free, click chemistry cycloaddition reactions with 1, 2, 4, 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules, without the need for a catalyst, to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported, and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility, less aggregation, and an increased distance between the amine to be modified and the reactive alkene.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable